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NEUROPIL THREADS
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DeCS
Descriptor
English
:
Neuropil Threads
Descriptor
Spanish
:
Hilos del Neurópilo
Descriptor
Portuguese
:
Filamentos do Neurópilo
Synonyms
English
:
Neuropil Thread
Tree Number:
A08.637.500.550
A08.675.703.550
A11.284.430.214.190.750.602.620
A11.650.500.550
A11.671.685.550
Definition
English
:
Abnormal structures located chiefly in distal
dendrites
and, along with
NEUROFIBRILLARY TANGLES
and SENILE PLAQUES, constitute the three morphological hallmarks of
ALZHEIMER DISEASE
.
Neuropil threads
are made up of straight and paired helical filaments which consist of abnormally phosphorylated microtubule-associated
tau proteins
. It has been suggested that the threads have a major role in the cognitive impairment seen in
Alzheimer disease.
Indexing Annotation
English
:
do not confuse with
NEUROPIL
, a "felt" of interwoven neuronal components &
neuroglia
History Note
English
:
98
Allowable Qualifiers
English
:
CH
chemistry
CL
classification
DE
drug effects
EN
enzymology
GE
genetics
IM
immunology
ME
metabolism
MI
microbiology
PS
parasitology
PA
pathology
PH
physiology
RE
radiation effects
TR
transplantation
UL
ultrastructure
VI
virology
Record Number:
33622
Unique Identifier:
D019600
Occurrence in VHL
:
Similar:
DeCS